Break Up Your Route
Now that you know how long the driving will take, it's time to figure out how to break it up. Resist the urge to "press on" too much or you’ll end up with cranky kids pulled over somewhere lame. A good guess is to allow for 4-5 hours between each long break and 2-3 hours between each bathroom break.
If you’ve got a cooler full of snacks and are looking to make the most of your trip, keep it fun and stop at Points of Interest for your long breaks and Rest Stops and Visitor Centers for your bathroom breaks. Check out the Roadtrippers App to help you out.
Points of Interest like historical landmarks, natural wonders, or nearby parks work great for long breaks to get your kids enough exercise and stimulation, food, and bathroom time. Then once you take off again, ten times out of ten, they start napping, and you get a couple of hours of peaceful driving time again.
Visitor Centers pop up when you cross a state line. They're great for stretching your legs, learning the local history, and pointing out where you are on a large scale map before hitting the road again. Rest stops are easy and usually have vending machines, picnic tables restrooms, and big trucks for kids to point at. Bring a Frisbee or ball of some kind in case the kids want to run around.
Decide on a mix between Points of Interest, Visitor Centers, Rest Stops, and gas stations. Plan a few to tell your kids about, but keep a few of them a surprise and a couple as backup.